Na_v1.7 Inhibitor

Na_v1.7 Inhibitors (34):

Cat. No.	Product Name	Effect	Purity

HY-N6691

Veratridine	Inhibitor	99.96%
Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC₅₀ of 18.39 µM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow.

HY-114237

GDC-0276	Inhibitor	99.95%
GDC-0276 is a potent, selective, reversible and orally active NaV1.7 inhibitor with an IC₅₀ value of 0.4 nM. GDC-0276 is well tolerated and exhibits a good pharmacokinetic profile. GDC-0276 has the potential for the treatment of pain and to address shortcomings of existing pain medications, such as addiction and off-target side effects.

HY-12796A

Raxatrigine hydrochloride	Inhibitor	98.94%
Raxatrigine hydrochloride (GSK-1014802 hydrochloride) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.

HY-131182

DS-1971a	Inhibitor	99.61%
DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC₅₀s of 22.8 and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects.

HY-118952A

PF-06456384 trihydrochloride	Inhibitor	99.77%
PF-06456384 trihydrochloride is a highly potent and selective Na_V1.7 inhibitor with an IC₅₀ of 0.01 nM. PF-06456384 trihydrochloride has the potential for formalin pain model research.

HY-162347

Nav1.7-IN-13	Inhibitor
Nav1.7-IN-13 (compound 3g) is a sodium channel inhibitor that significantly inhibits Veratridine (HY-N6691)-induced neuronal activity. Nav1.7-IN-13 inhibits total Na+ current in DRG neurons in a concentration-dependent manner; slows down the activation of Navs. Nav1.7-IN-13 significantly alleviated mechanical pain behavior in a rat model of nerve injury (SNI) and had analgesic activity.

HY-16723

Funapide	Inhibitor	99.72%
Funapide (TV 45070; XEN402) is a potent Sodium Channel Nav1.7 inhibitor.

HY-139081

GDC-0310	Inhibitor	99.80%
GDC-0310 is a selective acyl-sulfonamide Na_v1.7 inhibitor, with an IC₅₀ of 0.6 nM for hNa_v1.7.

HY-131870

GX-201	Inhibitor	99.14%
GX-201 is a selective Na_V1.7 inhibitor, with an IC₅₀ of <3.2 nM for hNa_V1.7.

HY-13985

Nav1.7 inhibitor	Inhibitor	99.99%
Nav1.7 inhibitor (compound II), a sulfonamide, is a potent Nav1.7 inhibitor. Nav1.7 inhibitor has the potential for a wide range of disorders, particularly pain.

HY-107405

TC-N 1752	Inhibitor	99.18%
TC-N 1752 is a potent and orally active inhibitor of Nav1.7, with IC₅₀s of 0.17 μM, 0.3 μM, 0.4 μM, 1.1 μM and 2.2 μM at hNav1.7, hNav1.3, hNav1.4, hNaV1.5 and rNav1.8, respectively. TC-N 1752 also inhibits tetrodotoxin-sensitive sodium channels. TC-N 1752 shows analgesic efficacy in the Formalin model of pain.

HY-100727

AM-2099	Inhibitor	98.06%
AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 with an IC₅₀ of 0.16 μM for human Nav1.7.

HY-12883A

PF-05198007	Inhibitor	99.77%
PF-05198007 is a potent, orally active and selective arylsulfonamide Na_v1.7 inhibitor. PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771.

HY-146069

ABBV-318	Inhibitor	98.97%
ABBV-318 is a potent Nav1.7/ Nav1.8 blocker, with IC₅₀s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively. ABBV-318 can be used for the research of pain.

HY-112279

GNE-131	Inhibitor	98.97%
GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC₅₀ of 3 nM.

HY-16723A

(R)-Funapide	Inhibitor	98.05%
(R)-Funapide ((R)-TV 45070) is the less active R-enantiomer of Funapide. Funapide is a potent Nav1.7 sodium channel blocker that can be used for pain research.

HY-119934

NaV1.7 inhibitor-1	Inhibitor	99.65%
NaV1.7 inhibitor-1 is an efficacious voltage-gated sodium channel (NaV) 1.7 inhibitor with an IC₅₀ of 0.6 nM for hNaV1.7, exhibits 80-fold selectivity versus hNaV1.5.

HY-12796

Raxatrigine	Inhibitor	99.85%
Raxatrigine (GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.

HY-102998

Nav1.7-IN-6	Inhibitor
Nav1.7-IN-6 (example 346) is a Nav1.7 selective inhibitor, which is extracted from patent WO2015078374A1.

HY-126291

GNE-616	Inhibitor
GNE-616 is a highly potent, metabolically stable, orally bioavailable, and subtype selective Nav1.7 inhibitor (K_i of 0.79 nM and K_d of 0.38 nM for hNav1.7) for the treatment of chronic pain. GNE-616 shows >1000 nM K_d and >2500-fold selectivity over hNav1.1, hNav1.3, hNav1.4, and hNav1.5. Selectivity over hNav1.2 and hNav1.6 is more modest at 31- and 73-fold, respectively.

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